Explaining differences in the severity of familial adenomatous polyposis and the search for modifier genes.
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چکیده
genes adenomatous polyposis and the search for modifier Explaining differences in the severity of familial service Email alerting top right corner of the article Receive free email alerts when new articles cite this article-sign up in the box at the
منابع مشابه
COLORECTAL CANCER Explaining variation in familial adenomatous polyposis: relationship between genotype and phenotype and evidence for modifier genes
Background: Familial adenomatous polyposis (FAP) is characterised by variable phenotypic expression. Part of this is attributable to a relationship between APC genotype and phenotype but there remains significant intrafamilial variation. In the Min mouse model of FAP, differences in the severity of gastrointestinal polyposis result from the action of modifier genes. Aims: To determine whether p...
متن کاملExplaining variation in familial adenomatous polyposis: relationship between genotype and phenotype and evidence for modifier genes.
BACKGROUND Familial adenomatous polyposis (FAP) is characterised by variable phenotypic expression. Part of this is attributable to a relationship between APC genotype and phenotype but there remains significant intrafamilial variation. In the Min mouse model of FAP, differences in the severity of gastrointestinal polyposis result from the action of modifier genes. AIMS To determine whether p...
متن کاملLeading article Explaining diVerences in the severity of familial adenomatous polyposis and the search for modifier genes
Familial adenomatous polyposis (FAP) has become the focus of several convergent lines of scientific and medical enquiry. The year 2000 has seen the completion of the human genome project and this coincides with the next major challenge of cancer genetics, non-mendelian inheritance. Colorectal cancer remains a major source of morbidity and mortality in developed countries. Despite huge advances ...
متن کاملLeading article Explaining diVerences in the severity of familial adenomatous polyposis and the search for modifier genes
Familial adenomatous polyposis (FAP) has become the focus of several convergent lines of scientific and medical enquiry. The year 2000 has seen the completion of the human genome project and this coincides with the next major challenge of cancer genetics, non-mendelian inheritance. Colorectal cancer remains a major source of morbidity and mortality in developed countries. Despite huge advances ...
متن کاملFamilial adenomatous polyposis, diagnosis and surveillance strategies: review article
Familial adenomatous polyposis is characterized by over 100 colorectal adenomas in the colorectum. The disease equally affects both sexes, with an incidence estimated at 1.14025-1.8300. The disease is premature in people with familial adenomatous polyposis. Patients suffering from familial adenomatous polyposis have a range of extra-intestinal diseases such as papillae, gastric, small intestine...
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ورودعنوان ژورنال:
- Gut
دوره 48 1 شماره
صفحات -
تاریخ انتشار 2001